Endocrine Abstracts

Introduction: Proinsulin is a propeptide of insulin and C-peptide during physiological insulin production and is increased in patients with type 2 diabetes. Increased proinsulin in peripheral blood indicates impairment of cleavage capacity to process insulin within the beta cell. Recently, chemiluminescence assays have been developed that are able to specifically measure uncleaved intact proinsulin in peripheral blood. In this cross-sectional study, we investigated the relatio...